ADB-FUBHQUCA

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Drug
iupac_name (S)-N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1,4-dihydroquinoline-3-carboxamide
width 200px
routes_of_administration
excretion
pubchem 165361603
smiles NC(=O)[C@@H](NC(=O)C=1Cc2ccccc2N(C=1)Cc1ccc(F)cc1)C(C)(C)C
c 23
h 26
f 1
n 3
o 2
stdinchi 1S/C23H26FN3O2/c1-23(2,3)20(21(25)28)26-22(29)17-12-16-6-4-5-7-19(16)27(14-17)13-15-8-10-18(24)11-9-15/h4-11,14,20H,12-13H2,1-3H3,(H2,25,28)(H,26,29)
stdinchikey WEFDGWANUSMUJL-UHFFFAOYSA-N

ADB-FUBHQUCA হলো একটি সিন্থেটিক ক্যানাবিনয়েড রিসেপ্টর অ্যাগোনিস্ট, যা ডিজাইনার ড্রাগ হিসেবে বিক্রি করা হয়। এটি প্রথম ২০২২ সালে শনাক্ত করা হয়েছিল।[1] এটি পূর্বে পরিচিত যৌগ ADB-FUBICA-এর সাথে সম্পর্কিত, তবে এতে কেন্দ্রীয় ইনডোল রিং সিস্টেমটিকে প্রসারিত করে একটি ১,৪-ডাইহাইড্রোকুইনোলিন কাঠামো তৈরি করা হয়েছে। এই পরিবর্তনের ফলে রিং সিস্টেমের অ্যারোমেটিসিটি (aromaticity) নষ্ট হয়ে যায় এবং সংশ্লিষ্ট অন্যান্য যৌগের তুলনায়, যেখানে অ্যারোমেটিক কোর অক্ষুণ্ণ থাকে, ADB-FUBHQUCA-এর কার্যকারিতা তুলনামূলকভাবে কম।[2][3][4][5][6][7][8][9][10][11][12][13]

আরও দেখুন

তথ্যসূত্র

  1. ↑ (18 February 2022). New Substance Report. 118. ADB-FUBHQUCA. AIPSIN monitoring.
  2. ↑ (2022). Cumyl-PeGaClone and other recently encountered synthetic cannabinoid receptor agonists. A review of the evidence on their use and harms.. Advisory Council on the Misuse of Drugs.
  3. ↑ (April 2023). "From JWH-018 to OXIZIDS: Structural evolution of synthetic cannabinoids in the European Union from 2008 to present day". Drug Testing and Analysis. 15 (4) 378–387. doi:10.1002/dta.3422.
  4. ↑ (April 2004). "Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors". Bioorganic & Medicinal Chemistry. 12 (8) 1921–1933. doi:10.1016/j.bmc.2004.01.035.
  5. ↑ (January 2006). "Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling". Journal of Medicinal Chemistry. 49 (1) 70–79. doi:10.1021/jm050467q.
  6. ↑ (October 2006). "Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists". Journal of Medicinal Chemistry. 49 (20) 5947–5957. doi:10.1021/jm0603466.
  7. ↑ (November 2007). "Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality". Journal of Medicinal Chemistry. 50 (22) 5471–5484. doi:10.1021/jm070387h.
  8. ↑ (December 2007). "New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists". Bioorganic & Medicinal Chemistry Letters. 17 (23) 6505–6510. doi:10.1016/j.bmcl.2007.09.089.
  9. ↑ (August 2008). "Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo". Journal of Medicinal Chemistry. 51 (16) 5075–5084. doi:10.1021/jm800552f.
  10. ↑ (June 2009). "Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists". Journal of Medicinal Chemistry. 52 (12) 3644–3651. doi:10.1021/jm801563d.
  11. ↑ (August 2010). "Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands". Journal of Medicinal Chemistry. 53 (16) 5915–5928. doi:10.1021/jm100123x.
  12. ↑ (August 2011). "Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice". Journal of Medicinal Chemistry. 54 (15) 5444–5453. doi:10.1021/jm200476p.
  13. ↑ (December 2012). "Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors". European Journal of Medicinal Chemistry. 58 30–43. doi:10.1016/j.ejmech.2012.09.035.

উৎস: ইংরেজি উইকিপিডিয়ার “ADB-FUBHQUCA” নিবন্ধের অনুবাদ। মূল নিবন্ধ: https://en.wikipedia.org/wiki/ADB-FUBHQUCA এই অনুবাদটি স্বয়ংক্রিয়ভাবে প্রস্তুত করা হয়েছে।

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