Digantasen: ইংরেজি উইকিপিডিয়ার “ADB-FUBHQUCA” নিবন্ধের বাংলা অনুবাদ

2026-10-15T08:38:00Z

ইংরেজি উইকিপিডিয়ার “ADB-FUBHQUCA” নিবন্ধের বাংলা অনুবাদ

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[[File:ADB-FUBHQUCA structure.svg|thumb]]
{| class="wikitable"
! colspan="2" | Drug
|-
| '''iupac_name''' || (S)-N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1,4-dihydroquinoline-3-carboxamide
|-
| '''width''' || 200px

|-
| '''routes_of_administration''' || 
|-
| '''excretion''' || 
|-
| '''pubchem''' || 165361603
|-
| '''smiles''' || NC(=O)[C@@H](NC(=O)C=1Cc2ccccc2N(C=1)Cc1ccc(F)cc1)C(C)(C)C


|-
| '''c''' || 23
|-
| '''h''' || 26
|-
| '''f''' || 1
|-
| '''n''' || 3
|-
| '''o''' || 2
|-
| '''stdinchi''' || 1S/C23H26FN3O2/c1-23(2,3)20(21(25)28)26-22(29)17-12-16-6-4-5-7-19(16)27(14-17)13-15-8-10-18(24)11-9-15/h4-11,14,20H,12-13H2,1-3H3,(H2,25,28)(H,26,29)
|-
| '''stdinchikey''' || WEFDGWANUSMUJL-UHFFFAOYSA-N
|}

'''ADB-FUBHQUCA''' হলো একটি [[wikipedia:Synthetic cannabinoid|সিন্থেটিক ক্যানাবিনয়েড]] রিসেপ্টর অ্যাগোনিস্ট, যা [[wikipedia:Designer drug|ডিজাইনার ড্রাগ]] হিসেবে বিক্রি করা হয়। এটি প্রথম ২০২২ সালে শনাক্ত করা হয়েছিল।<ref>(18 February 2022). [https://aipsin.com/newsubstance/806/ New Substance Report. 118. ADB-FUBHQUCA]. ''AIPSIN monitoring''.</ref> এটি পূর্বে পরিচিত যৌগ [[wikipedia:ADB-FUBICA|ADB-FUBICA]]-এর সাথে সম্পর্কিত, তবে এতে কেন্দ্রীয় [[wikipedia:Indole|ইনডোল]] রিং সিস্টেমটিকে প্রসারিত করে একটি ১,৪-ডাইহাইড্রো[[wikipedia:Quinoline|কুইনোলিন]] কাঠামো তৈরি করা হয়েছে। এই পরিবর্তনের ফলে রিং সিস্টেমের অ্যারোমেটিসিটি (aromaticity) নষ্ট হয়ে যায় এবং সংশ্লিষ্ট অন্যান্য যৌগের তুলনায়, যেখানে অ্যারোমেটিক কোর অক্ষুণ্ণ থাকে, ADB-FUBHQUCA-এর কার্যকারিতা তুলনামূলকভাবে কম।<ref>(2022). [https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1159142/Cumyl-pegalone_and_other_uncontrolled_SCRA_report-FINAL.pdf Cumyl-PeGaClone and other recently encountered synthetic cannabinoid receptor agonists. A review of the evidence on their use and harms.]. ''Advisory Council on the Misuse of Drugs''.</ref><ref name="pmid36507715">(April 2023). "From JWH-018 to OXIZIDS: Structural evolution of synthetic cannabinoids in the European Union from 2008 to present day". ''Drug Testing and Analysis''. 15 (4) 378–387. doi:[https://doi.org/10.1002/dta.3422 10.1002/dta.3422].</ref><ref name="pmid15051060">(April 2004). "Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors". ''Bioorganic & Medicinal Chemistry''. 12 (8) 1921–1933. doi:[https://doi.org/10.1016/j.bmc.2004.01.035 10.1016/j.bmc.2004.01.035].</ref><ref name="pmid16392793">(January 2006). "Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling". ''Journal of Medicinal Chemistry''. 49 (1) 70–79. doi:[https://doi.org/10.1021/jm050467q 10.1021/jm050467q].</ref><ref name="pmid17004710">(October 2006). "Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists". ''Journal of Medicinal Chemistry''. 49 (20) 5947–5957. doi:[https://doi.org/10.1021/jm0603466 10.1021/jm0603466].</ref><ref name="pmid17915849">(November 2007). "Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality". ''Journal of Medicinal Chemistry''. 50 (22) 5471–5484. doi:[https://doi.org/10.1021/jm070387h 10.1021/jm070387h].</ref><ref name="pmid17942307">(December 2007). "New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists". ''Bioorganic & Medicinal Chemistry Letters''. 17 (23) 6505–6510. doi:[https://doi.org/10.1016/j.bmcl.2007.09.089 10.1016/j.bmcl.2007.09.089].</ref><ref name="pmid18680276">(August 2008). "Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo". ''Journal of Medicinal Chemistry''. 51 (16) 5075–5084. doi:[https://doi.org/10.1021/jm800552f 10.1021/jm800552f].</ref><ref name="pmid19435366">(June 2009). "Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists". ''Journal of Medicinal Chemistry''. 52 (12) 3644–3651. doi:[https://doi.org/10.1021/jm801563d 10.1021/jm801563d].</ref><ref name="pmid20718492">(August 2010). "Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands". ''Journal of Medicinal Chemistry''. 53 (16) 5915–5928. doi:[https://doi.org/10.1021/jm100123x 10.1021/jm100123x].</ref><ref name="pmid21702498">(August 2011). "Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice". ''Journal of Medicinal Chemistry''. 54 (15) 5444–5453. doi:[https://doi.org/10.1021/jm200476p 10.1021/jm200476p].</ref><ref name="pmid23085772">(December 2012). "Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors". ''European Journal of Medicinal Chemistry''. 58 30–43. doi:[https://doi.org/10.1016/j.ejmech.2012.09.035 10.1016/j.ejmech.2012.09.035].</ref>

== আরও দেখুন ==
* [[ADB-FUBIATA|ADB-FUBIATA]]
* [[S-444,823|S-444,823]]
* [[S-777,469|S-777,469]]
* [[SER-601|SER-601]]

== তথ্যসূত্র ==
<references />

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''উৎস:'' ইংরেজি উইকিপিডিয়ার “ADB-FUBHQUCA” নিবন্ধের অনুবাদ।
''মূল নিবন্ধ:'' https://en.wikipedia.org/wiki/ADB-FUBHQUCA
''এই অনুবাদটি স্বয়ংক্রিয়ভাবে প্রস্তুত করা হয়েছে।''

ADB-FUBHQUCA - Revision history

Digantasen: ইংরেজি উইকিপিডিয়ার “ADB-FUBHQUCA” নিবন্ধের বাংলা অনুবাদ