https://ltrc.sciwiki.in/index.php?action=history&feed=atom&title=ADB-BINACA ADB-BINACA - Revision history 2026-10-17T18:19:04Z Revision history for this page on the wiki MediaWiki 1.43.9 https://ltrc.sciwiki.in/index.php?title=ADB-BINACA&diff=6445&oldid=prev Digantasen: ইংরেজি উইকিপিডিয়ার “ADB-BINACA” নিবন্ধের বাংলা অনুবাদ 2026-10-15T08:37:40Z <p>ইংরেজি উইকিপিডিয়ার “ADB-BINACA” নিবন্ধের বাংলা অনুবাদ</p> <p><b>New page</b></p><div>vanc<br /> [[File:ADB-BINACA structure.svg|thumb]]<br /> {| class=&quot;wikitable&quot;<br /> ! colspan=&quot;2&quot; | Drug<br /> |-<br /> | &#039;&#039;&#039;iupac_name&#039;&#039;&#039; || &#039;&#039;N&#039;&#039;-[(2&#039;&#039;S&#039;&#039;)-1-amino-3,3-dimethyl-1-oxobutan-2-yl]-1-benzyl-1&#039;&#039;H&#039;&#039;-indazole-3-carboxamide<br /> |-<br /> | &#039;&#039;&#039;pregnancy_au&#039;&#039;&#039; || &lt;!-- A / B1 / B2 / B3 / C / D / X --&gt;<br /> |-<br /> | &#039;&#039;&#039;pregnancy_us&#039;&#039;&#039; || &lt;!-- A / B / C / D / X --&gt;<br /> |-<br /> | &#039;&#039;&#039;legal_au&#039;&#039;&#039; || &lt;!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --&gt;<br /> |-<br /> | &#039;&#039;&#039;legal_ca&#039;&#039;&#039; || Schedule II<br /> |-<br /> | &#039;&#039;&#039;legal_de&#039;&#039;&#039; || NpSG<br /> |-<br /> | &#039;&#039;&#039;legal_uk&#039;&#039;&#039; || Class B<br /> |-<br /> | &#039;&#039;&#039;legal_us&#039;&#039;&#039; || Schedule I<br /> |-<br /> | &#039;&#039;&#039;routes_of_administration&#039;&#039;&#039; || &lt;!--Pharmacokinetic data--&gt;<br /> |-<br /> | &#039;&#039;&#039;excretion&#039;&#039;&#039; || &lt;!--Identifiers--&gt;<br /> |-<br /> | &#039;&#039;&#039;cas_number_ref&#039;&#039;&#039; || ??<br /> |-<br /> | &#039;&#039;&#039;cas_number&#039;&#039;&#039; || 1185282-27-2<br /> |-<br /> | &#039;&#039;&#039;unii_ref&#039;&#039;&#039; || FDA<br /> |-<br /> | &#039;&#039;&#039;unii&#039;&#039;&#039; || PUVP61SOSI<br /> |-<br /> | &#039;&#039;&#039;pubchem&#039;&#039;&#039; || 129406620<br /> |-<br /> | &#039;&#039;&#039;chemspiderid&#039;&#039;&#039; || 57621565<br /> |-<br /> | &#039;&#039;&#039;smiles&#039;&#039;&#039; || O=C(NC(C(N)=O)C(C)(C)C)C1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3<br /> |-<br /> | &#039;&#039;&#039;stdinchi&#039;&#039;&#039; || 1S/C21H24N4O2/c1-21(2,3)18(19(22)26)23-20(27)17-15-11-7-8-12-16(15)25(24-17)13-14-9-5-4-6-10-14/h4-12,18H,13H2,1-3H3,(H2,22,26)(H,23,27)<br /> |-<br /> | &#039;&#039;&#039;stdinchikey&#039;&#039;&#039; || IUFIUAWRCUVUCQ-UHFFFAOYSA-N<br /> <br /> &lt;!--Chemical data--&gt;<br /> |-<br /> | &#039;&#039;&#039;c&#039;&#039;&#039; || 21<br /> |-<br /> | &#039;&#039;&#039;h&#039;&#039;&#039; || 24<br /> |-<br /> | &#039;&#039;&#039;n&#039;&#039;&#039; || 4<br /> |-<br /> | &#039;&#039;&#039;o&#039;&#039;&#039; || 2<br /> |}<br /> <br /> &#039;&#039;&#039;ADB-BINACA&#039;&#039;&#039; (যা EMCDDA নামকরণের মানদণ্ড অনুযায়ী &#039;&#039;&#039;ADMB-BZINACA&#039;&#039;&#039; নামেও পরিচিত&lt;ref&gt;(March 2023). &quot;EMCDDA framework and practical guidance for naming synthetic cannabinoids&quot;. &#039;&#039;Drug Testing and Analysis&#039;&#039;. 15 (3) 255–276. doi:[https://doi.org/10.1002/dta.3403 10.1002/dta.3403].&lt;/ref&gt;) হলো একটি [[ক্যানাবিনয়েড|ক্যানাবিনয়েড]] ডিজাইনার ড্রাগ (designer drug), যা কিছু সিন্থেটিক ক্যানাবিস পণ্যের উপাদান হিসেবে পাওয়া গেছে।&lt;ref&gt;(2016). &quot;Four types of cannabimimetic indazole and indole derivatives, ADB-BINACA, AB-FUBICA, ADB-FUBICA, and AB-BICA, identified as new psychoactive substances&quot;. &#039;&#039;Forensic Toxicology&#039;&#039;. 34 133–143. doi:[https://doi.org/10.1007/s11419-015-0297-2 10.1007/s11419-015-0297-2].&lt;/ref&gt; এটি মূলত ফাইজার (Pfizer) কর্তৃক একটি সম্ভাব্য বেদনানাশক (analgesic) হিসেবে তৈরি করা হয়েছিল। এটি [[wikipedia:CB1 receptor|CB&lt;sub&gt;1&lt;/sub&gt; রিসেপ্টর]]-এর একটি শক্তিশালী [[অ্যাগোনিস্ট|অ্যাগোনিস্ট]] (agonist), যার বাইন্ডিং অ্যাফিনিটি (binding affinity) (K&lt;sub&gt;i&lt;/sub&gt;) ০.৩৩ nM এবং [[wikipedia:EC50|EC&lt;sub&gt;50&lt;/sub&gt;]] ১৪.৭ nM।&lt;ref&gt;WO&lt;/ref&gt;<br /> <br /> == Adb-Butinaca ==<br /> ইন্ডাজল রিং-এ ১-বেনজাইল-এর পরিবর্তে ১-বিউটাইল প্রতিস্থাপনযুক্ত অ্যানালগটিও ADB-BINACA নামে ডিজাইনার ড্রাগ হিসেবে বিক্রি হয়েছে। তবে বেনজাইল যৌগের সাথে বিভ্রান্তি এড়াতে এখন এটিকে সাধারণত [[wikipedia:ADB-BUTINACA|ADB-BUTINACA]] নামে অভিহিত করা হয়।&lt;ref&gt;(July 2022). &quot;Detection of ADB-BUTINACA Metabolites in Human Urine, Blood, Kidney and Liver&quot;. &#039;&#039;Journal of Analytical Toxicology&#039;&#039;. 46 (6) 641–650. doi:[https://doi.org/10.1093/jat/bkab088 10.1093/jat/bkab088].&lt;/ref&gt;&lt;ref&gt;(November 2021). &quot;Urinary Metabolite Biomarkers for the Detection of Synthetic Cannabinoid ADB-BUTINACA Abuse&quot;. &#039;&#039;Clinical Chemistry&#039;&#039;. 67 (11) 1534–1544. doi:[https://doi.org/10.1093/clinchem/hvab134 10.1093/clinchem/hvab134].&lt;/ref&gt;&lt;ref&gt;(April 2022). [https://discovery.dundee.ac.uk/en/publications/a9c83a12-49d4-4b09-8f08-83bac57bcc24 The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons]. &#039;&#039;Drug Testing and Analysis&#039;&#039;. 14 (4) 634–652. doi:[https://doi.org/10.1002/dta.3203 10.1002/dta.3203].&lt;/ref&gt;&lt;ref&gt;(July 2022). &quot;Quantification of MDMB-4en-PINACA and ADB-BUTINACA in human hair by gas chromatography-tandem mass spectrometry&quot;. &#039;&#039;Forensic Toxicology&#039;&#039;. 40 (2) 340–348. doi:[https://doi.org/10.1007/s11419-022-00615-z 10.1007/s11419-022-00615-z].&lt;/ref&gt;&lt;ref&gt;(October 2022). &quot;Clinical features associated with ADB-BUTINACA exposure in patients attending emergency departments in England&quot;. &#039;&#039;Clinical Toxicology&#039;&#039;. 60 (10) 1094–1098. doi:[https://doi.org/10.1080/15563650.2022.2101469 10.1080/15563650.2022.2101469].&lt;/ref&gt; এটি একইভাবে শক্তিশালী CB&lt;sub&gt;1&lt;/sub&gt; অ্যাগোনিস্ট, যার CB1-এর জন্য বাইন্ডিং অ্যাফিনিটি ০.২৯ nM এবং CB2-এর জন্য ০.৯১ nM, এবং CB1-এর জন্য EC&lt;sub&gt;50&lt;/sub&gt; ৬.৩৬ nM।&lt;ref&gt;(December 2020). &quot;Synthesis and &#039;&#039;in Vitro&#039;&#039; Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA&quot;. &#039;&#039;ACS Chemical Neuroscience&#039;&#039;. 11 (24) 4434–4446. doi:[https://doi.org/10.1021/acschemneuro.0c00644 10.1021/acschemneuro.0c00644].&lt;/ref&gt;&lt;ref&gt;(July 2021). &quot;Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB&lt;sub&gt;1&lt;/sub&gt; receptor activation assays: Part I-Synthesis, analytical characterization, and binding affinity for human CB&lt;sub&gt;1&lt;/sub&gt; receptors&quot;. &#039;&#039;Drug Testing and Analysis&#039;&#039;. 13 (7) 1383–1401. doi:[https://doi.org/10.1002/dta.3037 10.1002/dta.3037].&lt;/ref&gt;<br /> <br /> == আরও দেখুন ==<br /> * [[4F-MDMB-BINACA|4F-MDMB-BINACA]]<br /> * [[wikipedia:5F-AB-PINACA|5F-AB-PINACA]]<br /> * [[5F-ADB|5F-ADB]]<br /> * [[wikipedia:5F-ADB-PINACA|5F-ADB-PINACA]]<br /> * [[ADB-CHMINACA|ADB-CHMINACA]]<br /> * [[wikipedia:ADB-FUBICA|ADB-FUBICA]]<br /> * [[ADB-FUBINACA|ADB-FUBINACA]]<br /> * [[ADB-HEXINACA|ADB-HEXINACA]]<br /> * [[ADB-PINACA|ADB-PINACA]]<br /> * [[wikipedia:ADB-4en-PINACA|ADB-4en-PINACA]]<br /> <br /> == তথ্যসূত্র ==<br /> &lt;references /&gt;<br /> <br /> ----<br /> &#039;&#039;উৎস:&#039;&#039; ইংরেজি উইকিপিডিয়ার “ADB-BINACA” নিবন্ধের অনুবাদ।<br /> &#039;&#039;মূল নিবন্ধ:&#039;&#039; https://en.wikipedia.org/wiki/ADB-BINACA<br /> &#039;&#039;এই অনুবাদটি স্বয়ংক্রিয়ভাবে প্রস্তুত করা হয়েছে।&#039;&#039;</div> Digantasen