View source for ल्यूमॉर्फिन

{| class="infobox" style="float:right; clear:right; width:22em; margin:0 0 1em 1em; padding:0.2em; border:1px solid #a2a9b1; background:#f8f9fa; color:#202122; font-size:88%; line-height:1.5em; border-spacing:3px"
|+ style="font-size:125%; font-weight:bold; padding:0.2em" | L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-phenylalanyl-L-lysyl-L-valyl-L-valyl-L-threonyl-L-arginyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-alanyl-L-tyrosyl-L-serylglycyl-L-α-glutamyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-alanine
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | IUPAC name
| L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-phenylalanyl-L-lysyl-L-valyl-L-valyl-L-threonyl-L-arginyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-alanyl-L-tyrosyl-L-serylglycyl-L-α-glutamyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-alanine
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | Other names
| Dynorphin B-29; Dynorphin B (1–29)
|-
! colspan="2" style="background:#eaecf0; text-align:center" | Identifiers
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | CAS Number
| 93443-35-7
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | PubChem CID
| 16131065
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | ChemSpider
| 48063590
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | SMILES
| C[C@H]([C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc5ccccc5)NC(=O)CNC(=O)CNC(=O)[C@H](Cc6ccc(cc6)O)N)O
|-
! colspan="2" style="background:#eaecf0; text-align:center" | Properties
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | Formula
| C<sub>161</sub>H<sub>236</sub>N<sub>42</sub>O<sub>48</sub>
|-
! scope="row" style="text-align:left; vertical-align:top; padding-right:0.6em" | Molar mass
| 3527.85 g/mol
|}

'''ल्यूमॉर्फिन''', जिसे '''डाइनॉर्फिन B<sub>1–29</sub>''' के नाम से भी जाना जाता है, एक [[प्राकृतिक उत्पाद|प्राकृतिक रूप से पाया जाने वाला]] [[अंतर्जात ओपिओइड]] [[पेप्टाइड]] है।<ref name="Dynorphins 2009 review">(September 2009). "30 years of dynorphins—new insights on their functions in neuropsychiatric diseases". ''Pharmacology & Therapeutics''. 123 (3) 353–370. doi:[https://doi.org/10.1016/j.pharmthera.2009.05.006 10.1016/j.pharmthera.2009.05.006].</ref><ref name="pmid6689399">(December 1983). "Leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B". ''Biochemical and Biophysical Research Communications''. 117 (3) 695–701. doi:[https://doi.org/10.1016/0006-291X(83)91653-4 10.1016/0006-291X(83)91653-4].</ref><ref name="pmid6548137">(August 1984). "Leumorphin is a novel endogenous opioid peptide in man". ''Biochemical and Biophysical Research Communications''. 123 (1) 148–155. doi:[https://doi.org/10.1016/0006-291X(84)90392-9 10.1016/0006-291X(84)90392-9].</ref> [[प्रो-डाइनॉर्फिन]] (प्रीप्रोएनकेफेलिन B) के [[अवशेष (रसायन विज्ञान)|अवशेषों]] 226-254 के [[प्रोटीयोलाइटिक]] [[बंध विदलन|विदलन उत्पाद]] के रूप में व्युत्पन्न,<ref name="Tseng1995">Leon F. Tseng. (1 September 1995). [https://books.google.com/books?id=PhHTwIy9Wd8C&pg=PA171 Pharmacology of Opioid Peptides]. 171. CRC Press. ISBN 978-3-7186-5632-5.</ref><ref name="pmid2166790">(August 1990). [http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2166790 Affinity of drugs and peptides for U-69,593-sensitive and -insensitive kappa opiate binding sites: the U-69,593-insensitive site appears to be the beta endorphin-specific epsilon receptor]. ''The Journal of Pharmacology and Experimental Therapeutics''. 254 (2) 412–9.</ref> ल्यूमॉर्फिन एक नोनाकोसापेप्टाइड (29 [[अमीनो एसिड]] लंबा) है और इसका [[अमीनो एसिड अनुक्रम|अनुक्रम]] Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Ser-Gln-Glu-Asp-Pro-Asn-Ala-Tyr-Ser-Gly-Glu-Leu-Phe-Asp-Ala है। इसे [[पिट्रिलिसिन मेटालोपेप्टिडेज़ 1]] (जिसे पहले "''डाइनॉर्फिन-परिवर्तित एंजाइम''" कहा जाता था), जो [[एंडोपेप्टिडेज़]] परिवार का एक [[एंजाइम]] है, द्वारा और अधिक घटाकर [[डाइनॉर्फिन B]] (डाइनॉर्फिन B-13) और [[डाइनॉर्फिन B-14]] में बदला जा सकता है।<ref name="pmid1670956">(January 1991). "Subcellular localization, partial purification, and characterization of a dynorphin processing endopeptidase from bovine pituitary". ''Journal of Neurochemistry''. 56 (1) 320–9. doi:[https://doi.org/10.1111/j.1471-4159.1991.tb02598.x 10.1111/j.1471-4159.1991.tb02598.x].</ref><ref name="pmid7559562">(October 1995). "Purification and characterization of a dynorphin-processing endopeptidase". ''The Journal of Biological Chemistry''. 270 (40) 23845–50. doi:[https://doi.org/10.1074/jbc.270.40.23845 10.1074/jbc.270.40.23845].</ref><ref name="pmid10360838">(May 1999). "Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases". ''DNA and Cell Biology''. 18 (5) 369–80. doi:[https://doi.org/10.1089/104454999315268 10.1089/104454999315268].</ref> ल्यूमॉर्फिन प्रो-डाइनॉर्फिन के अन्य अंतर्जात ओपिओइड पेप्टाइड डेरिवेटिव्स की तरह ही एक शक्तिशाली और चयनात्मक [[κ-ओपिओइड रिसेप्टर]] [[एगोनिस्ट]] के रूप में कार्य करता है।<ref name="pmid6149506">(September 1984). "Human leumorphin is a potent, kappa opioid receptor agonist". ''Neuroscience Letters''. 50 (1–3) 49–52. doi:[https://doi.org/10.1016/0304-3940(84)90460-9 10.1016/0304-3940(84)90460-9].</ref><ref name="pmid7908725">(January 1994). "Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro". ''Neuroscience''. 58 (2) 331–40. doi:[https://doi.org/10.1016/0306-4522(94)90039-6 10.1016/0306-4522(94)90039-6].</ref>

== इन्हें भी देखें ==
* [[ओपिओइड पेप्टाइड]]

== संदर्भ ==
<div class="reflist" style="column-width:30em; font-size:90%">
<references />
</div>

[[Category:Kappa-opioid receptor agonists]]
[[Category:Opioid peptides]]

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''स्रोत:'' अंग्रेज़ी विकिपीडिया के "Leumorphin" लेख पर आधारित।
''मूल लेख:'' https://en.wikipedia.org/wiki/Leumorphin
''यह लेख स्वचालित रूप से तैयार किया गया है।''